Obesity – More Genetics Than Lifestyle

Obesity – More Genetics Than Lifestyle


Obesity, More Genetics Than Lifestyle? Obesity, together with malnutrition, remains
the great non-contagious epidemics of our time, however paradoxical their association
may be. There has been much speculation about the
causes of obesity, trying to stop or control it through a healthy lifestyle, diet or other
less orthodox methods of treatment such as dark chocolate or coffee, apart from the sought-after
“anti-obesity pill”, although they continue in it. In any case, genetics has always been targeted
as one of the great causes of this western epidemic, and it may be much more important
than we thought, although we should not give it more prominence than necessary. The role of genetics in obesity In fact, this time there has not been a study,
but up to two different investigations published in the prestigious journal Nature, which point
to genetics as a great cause of obesity, which could explain why some individuals are more
prone to suffer it, taking into account other related conditions, of course. The researchers analyzed samples of up to
300,000 people, detecting more than 140 genetic locations in their DNA that would play some
role in the development of obesity. Therefore we could not talk about a “gene
of obesity”, but it would be a polygenetic disease. In addition, new metabolic pathways were identified
with an important role in body weight and fat distribution. As a positive point, the
knowledge of these genes and new metabolic pathways can help us to develop new therapies
and drugs against this scourge, because these genes end up producing proteins that can be
blocked. The genetics of fat in obesity On the one hand, one of the studies focused
on how genes determine the place where fat is stored in our body, thus affecting our
health. This is important, since it is not the same
to store fat at the peripheral level (in arms or legs) than at the central level (belly
or belly). In the latter case, the storage of fat at the level of the belly has been
shown to increase the risk of suffering from other metabolic disorders such as type 2 diabetes
or cardiovascular diseases, as Karen Mohlke, professor of genetics at the University of
North Carolina, recalls. “Genes can determine the body’s location of
fat, thus posing different health risks. If we can find out which genes influence this
fat deposit, we could understand the biology that leads to suffering these health conditions,
such as insulin resistance or diabetes, the metabolic syndrome or heart disease ” The genetics of BMI in obesity On the other hand, in another research, they
focused on the relationship between genes and the body mass index (an estimate of body
fat according to height and weight, which is increasingly valued for its low specificity). It turned out that there were up to 97 genetic
associations related to BMI, and also the location of these genes was linked to areas
that control factors such as appetite or the use of energy by our body. This is the opinion of Dr. Elizabeth Speliotes,
the main author of this second research and professor of internal medicine and computational
medicine and bioinformatics at the University of Michigan: “Our work clearly demonstrates that the predisposition
to obesity and the increase in BMI does not depend on a single gene or genetic change.
A large number of genes involved makes it more complicated to find a solution to obesity,
and opens the door to new ways of genetic treatment ” Conclusion I think it is necessary to add a conclusion
to both studies: At no time has it been said that obesity is
purely genetic, eye, we are not saying that. We are talking about genetics playing an important
role, but not that “obesity is genetic”, and therefore if we suffer there is nothing to
do about it “because as it is genetic, it is not worth worrying about”. Mistake. That is not the attitude or way of
thinking. We are talking about different genes involved
in a certain part of the population being more predisposed to obesity, but that does
not mean that we should throw out a healthy diet, nor the right lifestyle, or all the
good health habits that we know work. So, please, let no one use studies like this
to say that “obesity is genetic and therefore it is impossible to fight against it” because
that is called lying to oneself. Learn “How To Lose 10 Pounds In 10 Days”.
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